BYM338 (Bimagrumab) for Inclusion Body Myositis – New cure or next dud?

Posted by Jeffrey Schneider, MSIV, Drexel University College of Medicine

There has recently been a flurry of news articles about a new treatment in clinical trials for Inclusion Body Myositis. Novartis has announced that BYM338 (Bimagrumab) has recently received FDA breakthrough status for the treatment of inclusion body myositis. What does this mean and what are the implications? Is this a cure or sensationalist hype? What do we need to know about BYM338 other than a sorely needed name change. Before we get to that let’s talk a little about inclusion body myositis.

What is Inclusion Body Myositis?

Inclusion Body Myositis (IBM) is a progressive disease of muscle weakness. Myositis, derived from Greek as many of our beloved medical terms are, is aptly named as it is a disease characterized by inflammation of the muscle. This disease most commonly presents insidiously with weakness of the fingers and quadriceps (thigh). This leads to difficulty with everyday activities like walking or holding objects. Some may also develop dysphagia (difficulty swallowing). The disease may occur sporadically (sIBM) and rarely as Hereditary IBM. It is not a fatal disease but the progressive muscle weakness means that many will rely on assistance for walking and everyday activity within 5 years.  This condition can often be difficult to diagnosis and can be aided with the help of a muscle biopsy.

Epidimiology

IBM is an age related disease that typically affects those 50 and older. Men are more often affected It is the most common of the inflammatory myopathies but is still a relatively rare condition

Differential Diagnosis

A common laboratory finding of myositis is an elevated in Creatine Kinase (CK).  CK, however, is not specific for just Inclusion Body Myositis and many conditions may also have this abnormal laboratory finding. More commonly cholesterol lowering drugs like Statins and Fibrates may lead to myositis. IBM may be mistaken for the other inflammatory myopathies, polymyositis and dermatomyositis. Polymyositis and dermatomyositis are treated with steroids and other immunosuppressive drugs of which have little effect on IBM which can sometimes be the clue that you might be dealing with IBM.

Pathology

The cause of IBM is not fully understood. What is evident is that there is an element of muscle inflammation and an element of muscle degeneration. A muscle biopsy will show the architecture of muscle at the microscopic level. Some of the key features that help to identify IBM are of course the inclusion body itself which are abnormal clumps of protein and tubules. Another feature are rimmed vacuoles which are empty pockets found within the cells. They are found in other inflammatory myopathies but occur in greater numbers in IBM.

Here is another biopsy slide showing some of the characteristic vacuoles and also the inflammatory cells in the endomysium (the layer that surrounds each individual muscle fiber).

Current Treatment

Unlike dermatomyositis and polymyositis there is currently no effective treatment of IBM.  Studies have shown the failure of steroids and other immunosuppressive agents.  Therefore it is approached symptomatically with physical therapy and exercise.

Where does that leave us now?

Novartis’ recent announcement is quite an interesting one. BYM338 (Bimagrumab) is a monoclonal antibody targeted to a very specific receptor on muscles cells. Monoclonal antibody therapy is a very field based on the human body’s own immune system.  B cells, a type of white blood cell, produce millions of variations on a common antibody to target infection. When the right antibody is found to bind to an infectious particle that B cell will undergo a series of interactions leading to cloning of that cell. This is the monoclonal proliferation that leads to a highly specific response. Researchers  have taken advantage of this concept to create highly targeted drugs.

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In the case of BYM338 (Bimagrumab), it is targeted to Type II Activin receptors on muscle tissue. This receptor normally binds an enzyme called Myostatin which inhibits muscle growth. By blocking this receptor the drug is blocking the effect of Myostatin and in theory allowing muscle growth. It is a novel approach to muscle degeneration seen in IBM.An interesting side note is that there is a breed of cattle with a defect in the gene for myostatin. The Breed is called Belgian Blue, their mutation leads to non-functioning Myostatin. They also look like this…

So is this the cure to IBM that we have been looking for. Currently the data has not been published so it is impossible to say. What we do now is that the FDA has approved BYM338 for “breakthrough” status. What this means is that the FDA is going to expedite the review of BYM338 based on what it has seen so far. This does not mean that it is a new breakthrough therapy that has passed all of its tests but rather that the FDA is intrigued by its prospects. It is also important to know that BYM338 has only gone through Phase II of Clinical trials. Phase I assesses the safety of a drug. Phase II trials are compared against placebo with a relatively small sample size (100-300). Phase 3 trials and FDA review will most likely take several more years before we will find out whether BYM338, or rather endearingly BYM338, lives up to its expectations. Could this drug be expanded to treat muscle wasting in cancer patients or the elderly? That is something developers are probably interested in but we currently don’t have the published data to support it. Could this effectively treat IBM? Maybe. Could this be a dud? Possibly. Will it be expensive? Most definitely.

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11 thoughts on “BYM338 (Bimagrumab) for Inclusion Body Myositis – New cure or next dud?

  1. Is your Institute also likely to join the Phase III trial with BYM338? If yes, when? If not, any trial center likely to open in the Barnabas Health Group or any other NJ facility?
    Thanks

    • Thanks for your comment. The Novartis sponsored Phase III trials are just about to open. Click here for more info. They are in Arizona, Ohio, Massachusetts, Kansas and Texas. Unfortunately, none so far in NY metro area.

  2. To my understanding, the pathology of sIBM and hIBM is the same. If that is correct, I presume the mechanism described in this article should apply to both types. If that is also correct, why is this new drug specifies sIBM?

  3. Excellent article.
    All IBM patients have biopsy to confirm diagnosis, just like for cancer patients. The tissues extracted are studied to check for IBM ( See the nice pictures in this article. ) For cancer patients, new drugs are often tested with tissues from their biopsies. My question is this: Has BYM338 been tested with tissue samples by the scientific labs and/or drug manufacturers? lastly, can we get access to the data submitted to FDA?

    • These are great comments! You are right, drug research can either be done on cell lines in a petri dish (in-vitro) or in live animals/humans with disease (in-vivo). There are cancer cell lines available for in-vitro research. There is no in-vitro model for IBM (yet). There are some specific animal models that were used in the BYMN338 research (myostatin knock out mice), but there isn’t a good animal model of IBM either. This means any clinical trials will have to be done in affected patients.

  4. http://www.Clinicaltrials.gov has the trial (NCT01925209) as Active but not recruiting.
    I was just diagnosed with sIBM in April and started IVIG infusions at the lab at Drexel. Going tomorrow for an infusion. I am very interested in entering the trial if at all possible once they do start recruiting.

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